CRISPR is the only way to combat posthumanism. Without the development of CRISPR as a tool, the transhumanist project has no future, no matter how much we have intervened in the ecology and are adapting the environment more than we adapt to it (climate change is a minor feat). The real break with natural selection is at the genetic, molecular level.
If it's not there, then it's not there at all.
https://www.redalyc.org/journal/5117/511769287026/html/