https://www.tga.gov.au/alert/clozapine
Information for consumers
If you or someone you provide care for is taking clozapine, you should contact a health professional immediately if constipation develops or there are any signs that bowel activity is slowing down, such as:
no bowel movements, bowel movements less often than usual, or difficulty passing a stool
nausea and/or vomiting
bloating, tenderness or swelling of the abdomen
stomach pains or spasms.
More information is available in the CMI for clozapine.
If you have any questions or concerns about this issue, talk to your health professional.
Information for health professionals
The PI for clozapine has been updated to reinforce and expand on existing warnings that severe gastrointestinal adverse reactions have occurred with its use. Gastrointestinal hypomotility induced by clozapine may lead to hospitalisation, surgery and death.