I think it's a crock of shit considering there's mutants among the guild and the Tiexelian ability to morph into any shape they so desired or their group's uncanny ability to revive dead humans with or without their previous consciousness.
I finishes Dune Messiah last night and felt it was missing the world building the first fitfully strived to push. The dialogue was ambiguous and lacked the page turning journey of the first. I'm glad Paul is dead. He's a mary sue and too easy to write for and rhat includes his spawn.
I do agree there's too many plot holes. Asimov is the better writer about ai, where as Herbert is the ecologist people were yearning for in his time.